Does Valproic Acid Induce Neuroendocrine Differentiation in Prostate Cancer?
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منابع مشابه
Does Valproic Acid Induce Neuroendocrine Differentiation in Prostate Cancer?
Valproic Acid (VPA) is a histone deacetylase inhibitor that holds promise for cancer therapy. Here, we investigate whether VPA treatment induces neuroendocrine differentiation of Prostate Cancer (PCa). A tissue microarray of VPA-treated and untreated tumor xenografts and cell lines of human PCa (LNCaP, C4-2, DU145, and PC-3) were generated and were analyzed by immunohistochemical analysis (IHC)...
متن کاملNeuroendocrine differentiation in prostate cancer.
As any organ in the body human prostate is composed of many different types of cells as well as extracellular components. During prostate development, reciprocal cellular interactions between stromal cells and prostate epithelial cells ultimately lead to the development of a mature prostate. Normal prostate is composed of repeating cellular units that contain stromal and epithelial compartments...
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Prostate cancer originates as an androgen-dependent hyperproliferation of the epithelial cells of the gland and it evolves in an androgen-independent, highly aggressive cancer for which no successful therapy is available to date. Neuroendocrine (NE) differentiation plays an important role in the progression of prostate cancer to an androgen-independent state with profound impact on prostate can...
متن کاملNeuroendocrine differentiation of prostate cancer.
Global Objectives: Review recent advances in the identification and diagnosis of current and emerging disease states. Discuss the pathophysiology of various disease states and the multidisciplinary considerations that affect patient care outcomes. Identify recent changes in requirements for accreditation, licensing, and regulatory compliance in across all divisions of pathology. Discuss...
متن کاملProstate cancer with neuroendocrine differentiation – case report
RATIONALE About 95% of prostate cancers are adenocarcinoamas. Depending on the detection method used, neuroendocrine cells are found in 10% to 100% of prostate cancer specimens. OBJECTIVE A 64-year-old patient was diagnosed in 2006 with adenocarcinoma of the prostate, PSA 4.1 ng/ml, Gleason 6, T3b, positive PSA immunohistochemistry. METHODS AND RESULTS The patient was started on hormone the...
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ژورنال
عنوان ژورنال: Journal of Biomedicine and Biotechnology
سال: 2011
ISSN: 1110-7243,1110-7251
DOI: 10.1155/2011/607480